When combined with previous studies that showed MAGL inhibitors such as JZL184 induce bone loss in healthy mice but reduce bone damage by inhibiting the growth of solid tumours [27], our current data reveal a complex role of MAGL and the body’s own cannabinoid system in the regulation of bone remodelling in solid [27, 32, 34] versus haematological ‘liquid’ malignancies such as MM. Here, MGLL is linked to Miyoshi myopathy.