NGFR and melanoma: Indeed, NGFR has been shown to play a tumor supportive role in a variety of cancers, such as enhancing cancer cell survival in breast cancers, squamous cell carcinomas, melanomas, and schwannoma, and promote an invasive phenotype in gliomas, melanomas, and head and neck carcinomas (Descamps et al., 2001; Okumura et al., 2006; Soland et al., 2008; Truzzi et al., 2008; Boiko et al., 2010; Civenni et al., 2011; Kim et al., 2012).