NGFR and central nervous system cancer: Our own studies have revealed the amplification of NGFR in gliomas (Zhou et al., 2016b), and our ongoing unpublished studies examining patient colorectal carcinoma (CRC) tumors indicate that not only NGFR is significantly higher expressed in CRC tumors compared with adjacent tissue, but NGFR is also associated with recurrent and metastatic CRC compared with non-recurrent and primary CRC.