TP73 and cancer: Although p73 is rarely found to be mutated in cancers, several mechanisms have been recognized that it can suppress p73 activity in cancer cells, including hypermethylation of the TP73 promoter or amplification of proteins that inhibit TAp73 activity (Corn et al., 1999; Kawano et al., 1999; Casciano et al., 2002; Guan and Chen, 2005).