Other HRS triggering events include severe alcoholic hepatitis, hypovolemia as the result of excess diuresis or gastrointestinal losses (bleeding or diarrhea), large volume shifts between intravascular and extravascular compartments, and use of medications that affect afferent or efferent arteriole constriction or vasodilation in the kidney (e.g., nonsteroidal anti-inflammatory drugs [NSAIDs], angiotensin-converting enzyme inhibitors [ACE-Is], angiotensin II receptor blockers [ARBs]) [5]. The gene discussed is ACE; the disease is alcoholic hepatitis.