Consistent with our observation, the recent studies of Chong-Hui Tang et al. and Derya Özsavcí et al. demonstrated that treatment with nesfatin-1 reduces the concentrations of inflammatory mediators such as interleukin-1 beta, tumor necrosis factor alpha, interleukin-6 after traumatic brain injury, and subarachnoid hemorrhage brain damage (Tang et al., 2012, Özsavcí et al., 2011). Here, NUCB2 is linked to subarachnoid hemorrhage.