Besides, anti-apoptotic and anti-inflammatory properties of nesfatin-1 have been recently reported in model subarachnoid hemorrhage and traumatic brain injury in rats that were created by the diminution of caspase-3 activity and pro-inflammatory cytokines secretion (Özsavcí et al., 2011, Tang et al., 2012). This evidence concerns the gene NUCB2 and subarachnoid hemorrhage.