SLC12A2 and Hypokalemia: As mentioned above and based on the results of most studies, administration of bumetanide was safe and had some minor adverse effects, which were mainly limited to hypokalemia (Hadjikhani et al., 2013; Lemonnier et al., 2012, 2017; Lemonnier et al., 2013; Lemonnier & Ben-Ari, 2010) the NKCC1 chloride-importer inhibitor bumetanide restores physiological (Cl-.