MRE11 and ataxia-telangiectasia-like disorder: For example, mutations in MRE11, TDP1 and aprataxin (APTX) result in neurodegenerative disorders such as A-T like disease (ATLD) [48], spinocerebellar ataxia with axonal neuropathy (SCAN1) [49], and ataxia-oculomotor apraxia-1 [50, 51] respectively.