To further predict the potential function of SLC4A4 in CRC, using the PPI network, we analyzed the interaction among 82 abnormal expressed genes and found that SLC4A4 might interact with SLC9A3, SLC26A6, ENSG00000214921, SLC26A4, DCTN1, AHCYL1, CA4, SLC9A3R1, SLC9A1, and CA2. This evidence concerns the gene SLC9A1 and colorectal carcinoma.