The study of SLC4A4 in colon cancer cells revealed that knockdown of SLC4A4 via shRNA reduced cell proliferation and mortality during external acidosis and spheroid growth, while pHi recovery from acidosis was partially reduced with knockdown of SLC4A438, while overexpression of SLC4A4 obviously suppressed the proliferation and metastasis of Caki-1 cells39, demonstrating that the role of SLC4A4 in cancers including CRC urgent need to be further addressed. The gene discussed is SLC4A4; the disease is malignant colon neoplasm.