The decrease of SLC4A4 mRNA expression in CRC tissues was further confirmed by analyses of Q-PCR based cDNA array (Fig. 2C; P<0.05) and IHC based TMA (Fig. 3; P<0.05), indicating that the expression of SLC4A4 in CRC tissues were down-regulated comparing with noncancerous colorectal tissues. Here, SLC4A4 is linked to colorectal carcinoma.