Based on the protein expression of SLC4A4 in CRC tissues of TMA, survival analysis indicated that lower SLC4A4 protein expression obviously associated with shorter survival of CRC patients (Fig. 4B; P<0.05), the representative image of high or low protein expression of SLC4A4 were shown in Fig. 4C. Association analyses between SLC4A4 expression and clinical characteristics didn't found obviously correlation between SLC4A4 expression with Age, Gender, Pathology, Tumor size, T stage, N stage and M stage (Table 3). Here, SLC4A4 is linked to neoplasm.