In fact, HEY1 is a candidate oncogene that is highly expressed in glioblastoma 33, 34, rhabdomyosarcoma 35, hepatocellular carcinoma 36, head and neck squamous cell carcinoma 37, and renal cell carcinoma 38, among other cancers. This evidence concerns the gene HEY1 and hereditary clear cell renal cell carcinoma.