Most of the samples included were kidney primary lesions (165) and seven were from distant metastasis of RCC including; samples from occipital dura, iliac bone, nasopharyngeal mass and neck lymph node from 4 HLRCC cases and 1 lung Metastasis (MT) from a CCRCC, 1 lung MT from a Type 1 PRCC and 1 Omentum sample from a SDHB mutated RCC. This evidence concerns the gene SDHB and renal cell adenocarcinoma.