The number of positive intratumoral cells for PD-L1 in each group varied with the tumor type; in TFE3 the mean was 56.7%; TFEB was 55%; Type 1 PRCC was 41.1% (range 15-80); undifferentiated was 38.3%; HLRCC cases was 34.5%; hybrid tumors was 30% and chromophobe was 25.7% . The gene discussed is CD274; the disease is hereditary leiomyomatosis and renal cell cancer.