Multivariate analysis indicated that ANXA8 expression (HR 2.293, 95% CI 1.317-3.991, p=0.003), lymph node metastasis (HR 3.572, 95% CI 2.047-6.233, p<0.001) and differentiation grade (HR 2.137, 95% CI 1.006-2.794, p=0.047) were associated with OS (Table 2). The gene discussed is ANXA8; the disease is metastatic malignant neoplasm in the lymph nodes.