Make use of vitro hepatocytes and in vitro liver culture systems, as well as human liver chimeric mice and HCC tissues, the researchers demonstrated that the ATX-LPA signal axis activates PI3K and stabilizes HIF-1 α, which positively regulates hepatitis C virus (HCV) RNA replication, and this process may be related to LPA1 and LPA3 receptors, promoting disease progression to liver fibrosis and hepatocellular carcinoma 129. This evidence concerns the gene SETD2 and hepatocellular carcinoma.