Make use of vitro hepatocytes and in vitro liver culture systems, as well as human liver chimeric mice and HCC tissues, the researchers demonstrated that the ATX-LPA signal axis activates PI3K and stabilizes HIF-1 α, which positively regulates hepatitis C virus (HCV) RNA replication, and this process may be related to LPA1 and LPA3 receptors, promoting disease progression to liver fibrosis and hepatocellular carcinoma 129. The gene discussed is ENPP2; the disease is Hepatic fibrosis.