LPA2 and LPA3 are targets of LPA-induced proliferation of HCT116 and LS174T colon cancer cells by specific RNA interference (RNAi), and LPA2 and LPA3 promote the proliferation of colon cancer cells through classical protein kinase C (cPKC)-mediated activation of the β-catenin pathway 71. This evidence concerns the gene LPAR2 and malignant colon neoplasm.