RHO and familial pancreatic carcinoma: In pancreatic cancer, the progress of PANC-1 cells can be promoted by LPA1 and LPA3, suggesting that LPAR1 and LPAR3 contribute to the movement and development of pancreatic cancer cells 80, while LPA actively inhibits the action of pancreatic cancer cells through LPAR2-Gα12/13-Rho signal transduction pathway 81.