Studies 18 have reported that 19 FLT3 can be ubiquitinated in a certain environment, which further supports the conclusion of our study: p62/SQSTM1 delivers FLT3-ITD proteins to the lysosome, where they are subsequently degraded, which provides a theoretical foundation to support the therapeutic potential of ATO in FLT3-ITD AML. Here, SQSTM1 is linked to acute myeloid leukemia.