Taken together, our data revealed a NF-κB/ miR-194-5p/IGF1R/PPFIBP1 axis in the oncogenesis of ovarian cancer, NF-κB binds directly to miR-194-5p promoter, leading to the downregulation of miR-194- 5p expression, which in turn facilitates the expression of IGF1R and PPFIBP1, and thereby promotes the oncogenesis of ovarian cancer. Here, PPFIBP1 is linked to ovarian carcinoma.