PPFIBP1 and ovarian carcinoma: Overexpression and knockdown PPFIBP1 respectively increased or inhibited SKOV3 and ES-2 cell proliferation (Fig. 5b and 5c), colony formation (Fig. 5d), migration and invasion (Fig. 5e and 5f), meaning that, similar as IGFR1, PPFIBP1 contributes to the oncogenesis of ovarian cancer.