Ribophorin II (RPN2), mediates CD63 glycosylation and as a portion of an N-oligosaccharyl transferase complex, can regulate drug resistance and invasion in breast cancer, cancer malignancy, and MDR1 localization.26 It has been reported that RPN2 correlates with a variety of malignant cancers, such as colorectal cancer,27 breast cancer,28 and so on. This evidence concerns the gene CD63 and colorectal cancer.