BMAL1 and atherosclerosis: This type of defects during early embryo development might allow the formation of viable newborns in Bmal1−/− mice that accumulate widespread minor developmental defects that will cause tissue misfunctioning during adult life, in agreement with reported phenotypes in life span, fertility, body weight, blood glucose and arthropathy, atherosclerosis, and hair growth (Kondratov et al, 2006; Yang et al, 2016).