After the recovery of SERCA activity (restoration of Ca2+ homeostasis), the levels of the ERS-related markers GRP78, SREBP, p-PERK, p-eIF2α, and CHOP are reduced, inhibiting the progression of NAFLD in L02 and BEL-7402 hepatoma cells [99, 100]. The gene discussed is DDIT3; the disease is metabolic dysfunction-associated steatotic liver disease.