Gonadotropin deficiency (FSH/LH) was most common pituitary hormone deficiency (137 patients, 91.3%), followed by ACTH (125 patients, 83.3%), GH (110 patients, 73.3%), and TSH (117 patients, 78.0%) deficiencies. The gene discussed is POMC; the disease is hyperinsulinemic hypoglycemia, familial, 4.