It was found that by comparing advanced fibrosis grades F3–F4 with HCC-NASH, serum AFP level has a moderate predictive power, where the area under the ROC curve was 0.751 (95% CI = 0.651–0.851) with 76.9% specificity, 69.1% accuracy, and 63.6% sensitivity. The gene discussed is AFP; the disease is hepatocellular carcinoma.