Based on the aforementioned, investigating different SNPs in IL-13 gene, IL13Rα1 gene, IL13Rα2 gene, STAT6 gene, YAP gene, PD-L1, and PD-L2 genes with fibrosis progression and HCC development in NASH have not been studied yet. This evidence concerns the gene IL13 and metabolic dysfunction-associated steatohepatitis.