Regarding genes polymorphisms, the association between IL-13 rs20541; IL-13R1 rs2248841; IL-13R2 rs5946040; STAT6 rs167769; YAP1 rs11225163; PD-L1 rs2282055; PD-L2 rs7854413 with cancer development in NASH were shown in Table 2. The gene discussed is CD274; the disease is metabolic dysfunction-associated steatohepatitis.