Univariate analysis showed that higher serum IL-13 levels (OR = 1.496 95%, CI = 1.111–2.014, p = 0.008), the presence of IL-13 rs20541 A allele carrier state (chi2 = 4.617, p = 0.034, OR = 2.722 95%, CI = 1.081–6.6858), the absence of IL-13R2 rs5946040 G allele carrier state (chi2 = 6.388, p = 0.018, OR = 0.194, 95% CI = 0.05–0.756), and the presence of PD-L2 rs7854413 C allele carrier state (chi2 = 7.495, p = 0.001, OR = 5.5 95% CI = 1.963–115.411) were all associated with advanced fibrosis grades in NASH patients, as shown in Table 4. The gene discussed is PDCD1LG2; the disease is metabolic dysfunction-associated steatohepatitis.