A predictive equation predicting the probability for HCC development in NASH patients (P) was estimated with formula:P = 1/1 + e− (− 17.996 + 0.693 × a + 3.101 × b + 0.247 × c-4.472 × d − 3.316 × e)where the substitution values were as follow: a: serum IL-13 levels (ng/L), b: log serum AFP levels (ng/mL), c: age of the patients in years, d: STAT6 rs167769 C/C genotype carrier=1, non-carrier=0, e: YAP1 rs11225163 C allele carrier = 1, non-carrier = 0. The gene discussed is AFP; the disease is metabolic dysfunction-associated steatohepatitis.