Similarly, the association of HCC development with lower fibrosis grades F1–F2 in NASH patients showed, also, that serum AFP levels alone has moderate predictive power, where the area under the ROC curve was 0.769 (95% CI = 0.67–0.868) with 92.5% specificity, 75.8% accuracy, and 63.6% sensitivity. This evidence concerns the gene AFP and hepatocellular carcinoma.