TNF and breast cancer: Within the past years, intensive research on tocotrienols, especially against breast cancer, has indicated that these isoprenoids can inhibit the tumor necrosis factor-alpha (TNF- α), activate p53, deactivate NF- kB which enable the downregulation of many gene products related to cell survival such as apoptosis inhibitors B-cell lym-phoma 2 (Bcl-2), proteins (IAP)-1, −2, B-cell lymphoma-extra-large (Bcl-xL), X-linked inhibitor of apoptosis (XIAP), survivin, cellular FLICE-like inhibitory protein (cFLIP), etc [59,69].