HR were 0.91 (0.78–1.05) for SG and 1.19 (1.00–1.42) for MAs (GBP as reference), 0.96 (0.95–0.97) for diabetes duration, 0.58 (0.43–0.79) for insulin treatment, 0.92 (0.90–0.96) for HbA1c and 1.01 (1.02–1.20) for weight loss at 1 year. The gene discussed is INS; the disease is diabetes mellitus.