In Huh7 hepatoma cells, infection with HCV leads to induction of the UPR and subsequently to an inhibition of the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian Target of the Rapamycin (mTOR) signaling pathway, resulting in induction of autophagy [16]. This evidence concerns the gene MTOR and hepatocellular carcinoma.