For example, even though tumor-suppressive roles of JNK signaling are suggested by some reports, including in breast cancer, our group has shown that high JNK activity correlates with poor outcome of TNBC patients and that JNK inhibition reduced CSC proliferation, NOTCH1 expression, and ALDH1 activity in multiple TNBC cell lines as well as in a preclinical mouse model [93]. This evidence concerns the gene MAPK8 and breast cancer.