Crucial transcription factors such as p53 or HIF-1α can regulate mitochondria homeostasis in cancer cells [39,40] and control the expression of enzymes involved in glycolysis and mitochondrial metabolism (glucose transporter, hexokinase II, 6-phosphofructokinase, pyruvate kinase, lactate dehydrogenase, cytochrome c oxidase subunit IV, glutaminaseetc). The gene discussed is COX4I1; the disease is cancer.