In addition to TECs, cancer-associated fibroblasts (CAFs) are yet another component of the tumor microenvironment that contributes to tumor remodeling and mediate the interaction with tumor-infiltrating immune cells.Moreover, CAFs have been shown to promote tumor angiogenesis by overexpressing WNT2 (Wnt family member 2) in colorectal cancer [10,11,12]. This evidence concerns the gene WNT2 and colorectal cancer.