Another study by the same group showed that in tumor-conditioned HUVECs (TC-HUVECs), the expression of Intracellular Adhesion Molecule 1 (ICAM-1) protein was down-regulated by 81% when compared to normal HUVECs, and decreased expression of Vascular Cell Adhesion Molecule 1 (VCAM-1) and E-selectin was also reported. Here, ICAM1 is linked to neoplasm.