Furthermore, when the confounding factors, such as age, SBP, eGFR, gender, HbA1c, duration of DM, and the use of dipeptidyl-peptidase-4 (DPP4) inhibitor, glucagon-like peptide-1 receptor (GLP-1R) agonist or sodium glucose co-transporters 2 (SGLT2) inhibitor were taken into consideration, KTR remained significant difference between responders and non-responders in the MAU group (Table 4). This evidence concerns the gene DPP4 and diabetes mellitus.