In particular, tumor-associated macrophages (TAM) can promote tumor progression through the secretion of specific factors such as cytokines (IL-10) and growth factors (vascular endothelial growth factor (VEGF), endothelin-2, and urokinase-type plasminogen activator) that contribute to the angiogenesis [13] and suppress the immune response. The gene discussed is VEGFA; the disease is neoplasm.