To examine whether FAM46C plays a role in prostate cancer response to chemotherapy, DU145 cells transduced with pLVX-Puro-FAM46C or blank pLVX-Puro lentivirus, while 22RV1 cells transduced with pLKO.1-FAM46C shRNA or pLKO.1-shNC, were treated with docetaxel. The gene discussed is TENT5C; the disease is Familial prostate cancer.