FAM46C was downregulated in hepatocellular carcinoma (HCC), induced cell apoptosis and cell cycle arrest at G2/M phase and inhibited HCC proliferation through regulating Ras/MEK/ERK pathway [12], and restrained HCC metastasis through regulating TGF-β/Smad and EMT process [13]. The gene discussed is MAP2K7; the disease is hepatocellular carcinoma.