By comparing the expression of FAM46C in cells, we revealed that, prostate cancer cell lines demonstrated a lower FAM46C expression compared with human prostate epithelial cell line RWPE-2, and 22RV1 cells had the higher expression of FAM46C while DU145 cells had the lower expression of FAM46C (Figure 1F). Here, TENT5C is linked to Familial prostate cancer.