To elucidate the mechanisms responsible for ALKBH1-mediated 6mA level in the Ang II-related hypertension model, our bioinformatics analysis revealed that human HIF1α gene had a 6mA motif [G/C]AGG[C/T] and was regulated by ALKBH1 [20, 21]. The gene discussed is HIF1A; the disease is hypertensive disorder.