Similarly, ALKBH1, the demethyltransferase of 6mA, was upregulated and negatively associated with 6mA DNA level in VSMCs of hypertensive mice or rats; the level of aortic N6AMT1, the methyltransferase of 6mA by hypertension, showed no change (Figure 2D–2I, Supplementary Figure 2A, 2B). Here, HEMK2 is linked to hypertensive disorder.