GPT and Cirrhosis: Having established that MARC1 p.A165T associates with protection from all-cause cirrhosis as well as fatty liver, we tested association of this variant with plasma biomarkers–ALT (alanine transaminase), AST (aspartate transaminase), ALP (alkaline phosphatase), total cholesterol, LDL (low-density lipoprotein) cholesterol, HDL (high-density lipoprotein) cholesterol, and triglycerides.