PNPLA3 and Hepatic steatosis: For example, PNPLA3 p.I48M and TM6SF2 p.E40K, although initially identified as associated with hepatic steatosis [9,10], strongly predispose to the development of alcoholic cirrhosis [11], non-alcoholic cirrhosis [12,13] and hepatitis C-related cirrhosis [14,15].