After demonstrating that known alcoholic and non-alcoholic variants associate with all-cause cirrhosis, we leverage the increased power provided by analysis of all-cause cirrhosis to identify a novel common protective missense variant in MARC1. We further identify a low-frequency coding variant and a rare stop codon in MARC1 that form an allelic series associated with lower cholesterol levels, lower liver enzyme levels and protection from cirrhosis. The gene discussed is MTARC1; the disease is Cirrhosis.