To study the contribution of IEC-intrinsic caspase-11 to overall host defense and the interplay of IFN-γ signaling, further infection studies using conditional knockout mice, cell culture, enteroids or less virulent strains of Salmonella (e.g. ΔaroA) as well as the evaluation of other cytokines induced during Salmonella infection will be required [32]. The gene discussed is IFNG; the disease is infection.