For instance, TNF (cachexin; note this patient's cachexia), released by TSST-1 exposed T cells, is vasoconstricting.[1] In addition, recent studies of skin vessels from laboratory animals chronically injected intradermally with staphylococcal or streptococcal SAgs demonstrate intraluminal aggregation and vessel wall infiltration by lymphocytes[1]; moreover, we have personally noted in peripheral blood smears of mycosis fungoides patients that Sezary cells tend to be aggregated. This evidence concerns the gene TNF and mycosis fungoides.