Recent research implicates that although lost E-cadherin is sufficient to introduce oncogenic transformation in prostatic epithelia, it also induces cell apoptosis and disrupts epithelial structure, preventing atypical prostatic intraepithelial neoplasia cells from progressing to tumor cells.[26] Hence, we hope this review will provide more accurate and objective shreds of evidence of the relationship between the E-cadherin and the prognosis of patients with PCa. The gene discussed is CDH1; the disease is prostate intraepithelial neoplasia.