INS and type 2 diabetes mellitus: Type 2 diabetes mellitus (T2DM) is a group of metabolic disorder characterized by the clinical feature of persistent hyperglycemia and pathophysiological characteristics of absolute or relative insufficiency of insulin.[1] Various chronic complications may occur in the later stage of T2DM, including diabetic macroangiopathy (DM).[2] DM is mainly composed of diabetic cardiovascular disease, ischemic stroke, and diabetic peripheral artery disease and is the leading cause of death for diabetic patients.