Alzheimer's disease (AD) is the most common cause of dementia worldwide and may afflict about 13.8 million people age 65 and older by 2050.[1] Its multifactorial pathogenesis remains elusive and may ascribe to genetic mutation, Aβ deposition, aberrant aggregation of Tau protein, intermediate neurons and network abnormalities, synaptic damage, mitochondrial dysfunction, endoplasmic reticulum stress function, cell autophagy, neuroinflammation and enteric dysbacteriosis.2, 3, 4, 5, 6, 7. The gene discussed is MAPT; the disease is Alzheimer disease.