Therefore, the current research was designed (a) to evaluate the correlation of the SYNE1 (rs2623963, rs7745725, rs1358317) and QK1 (rs9459317, rs1764053, rs1923608, rs16897566) single nucleotide polymorphisms (SNPs) and blood lipid spectrums in participants with hypercholesterolaemia (HCH) and/or hypertriglyceridaemia (HTG); (b) to assess the connection of their haplotypes with the possibility of HCH/HTG; and (c) to recognize the potential G × G as well as G × E interactions among these variants in the Maonan population. Here, SYNE1 is linked to hypertriglyceridemia.