Regarding the SNPs associated to IBD as well as to the methylation levels of IBD-DMPs, it is interesting that the methylation of a CpG island 4 kb upstream of the cg24032190-DMP identified in the first intron of SMAD3 has been reported to be allele-specific and to regulate the expression of the gene [50]. Here, SMAD3 is linked to inflammatory bowel disease.