Interestingly, other variants in the TRP domain of the p67phox protein have been previously reported in CGD patients who, as well, present a more severe clinical course (de Boer et al., 1994; Gentsch et al., 2010; Leusen et al., 1996; Martel et al., 2012; Patino et al., 1999). The gene discussed is NCF2; the disease is chronic granulomatous disease.