Lately, the function of homeobox genes in tumor growth and proliferation has been backed by several studies that have reported that many homeobox genes influence the tumors especially those of the digestive system.21, 22, 23, 24 Knight et al demonstrated by RNA‐seq analysis that expression of HOXD9 in normal‐appearing mucosa is significantly higher in the sigmoid colon compared to the rectum.25 But, the expression of HOXD9 in CRC is yet to be studied. This evidence concerns the gene HOXD9 and neoplasm.