It has been recently shown that HOXD9 encourages epithelial‐mesenchymal transition (EMT) and the spread of cancer by regulation of ZEB1.10 In contrast, knockdown of ZEB1 hinders the induction of HOXD9 invasion and EMT in carcinoma cells of the liver.11 Moreover, HOXD9 has been implicated as a tumor‐inducing factor in gastric cancer.12 But, the function of HOXD9 genes in the development and growth of CRC is yet to be revealed. This evidence concerns the gene ZEB1 and neoplasm.