Yang et al51 reported that complex SUV39H1/CRL4B/HP1/DNMT3A promoted DNA methylation‐based epigenetic silencing, while Spyropoulou et al52 also showed that histone lysine N‐methyltransferases, especially SUV39H1, led to malignancy in gliomas and is a potential biomarker. This evidence concerns the gene DNMT3A and glioma.