As shown in Figure 2A, the mRNA expressions of the KLFs were polarized; most KLF levels decreased in PCa tissue compared with in normal tissue, including KLF3, KLF4, KLF5, KLF6, KLF7, KLF8, KLF9, KLF10, KLF11, KLF12, KLF13 and KLF17 (P < .05). Here, KLF12 is linked to posterior cortical atrophy.