To further explore whether and how KLFs impact the process and prognosis of PCa, we calculated the risk score for each patient based on the following formula: risk score = 0.542*Gleason score + 0.559*pathology T stage −0.040*KLF5 + 0.077*KLF13 (Figure 3A, Table S4; see Section 2). Here, KLF5 is linked to posterior cortical atrophy.