The highly expressed ARHGDIG in the KLF‐P group leads to a poor prognosis of PCa (P = .00028, Figure 5C), and the expression of ARHGDIG in tumours is negatively associated with the KLF5 levels (R = −0.34, P < .001, Figure 5F), confirming the prognostic value of KLF5 in PCa. Here, ARHGDIG is linked to posterior cortical atrophy.