Subsequently, we adopted multivariate Cox proportional hazard regression analysis based on the nine positive factors, and demonstrated that the Gleason score (HR = 1.723, 95% CI: 1.301‐2.282, P < .001), pathological T stage (HR = 1.754, 95% CI: 1.03‐2.985, P = .038), KLF5 (HR = 0.96, 95% CI: 0.925‐0.998, P = .038) and KLF13 (HR = 1.08, 95% CI: 1.006‐1.159, P = .033) are independent prognostic factors of PCa (Table 1). Here, KLF5 is linked to posterior cortical atrophy.