SPP1 and metabolic dysfunction-associated steatohepatitis: The hampered HCC progression observed in OPN‐deficient mice and the specific overexpression of OPN at the HCC time point in livers of NASH‐HCC‐WT animals (Figure 7A,B) point toward a causative role for OPN in the dedifferentiation of HCCs harboured on a metabolic syndrome‐background.