Moreover mRNA expression of FOXO1 was markedly reduced in NASH‐HCC‐Spp1−/− livers (Figure 8D), and G6pc and Pck1 genes, which encode key gluconeogenic enzymes and are transcriptional targets of FOXO1, were suppressed in OPN‐deficient livers (Figure 8D, statistically significant only for G6pc). Here, FOXO1 is linked to hepatocellular carcinoma.