RHOT1 and Parkinson disease: Moreover, recent studies suggested that Miro1-mediated mitochondrial transport is especially important in PD, since human skin fibroblasts and iPSC-derived neurons expressing LRRK2 or SNCA mutations cause a stabilization of Miro1 on damaged mitochondria, interfering with their detachment from the transport machinery and, consequently, prohibiting mitophagy (34,35,40).