MAPT and early-onset autosomal dominant Alzheimer disease: On average, the αSyn content of these HMW SEC fractions comprised only 1.0% (in control cortex) and 1.4% (in DLB cortex) of the total eluted cytosolic αSyn, indicating that in the diseased brain, HMW-soluble αSyn species is relatively elevated but still not abundant, similar to previous observations of tau protein species present in Alzheimer’s disease brain (Takeda et al., 2015).