SNCA and Parkinson disease: To date, six different point mutations within the SNCA gene have been linked to early-onset PD and/or DLB, indicating that αSyn abnormalities can be causative in the pathogenesis of these diseases (Polymeropoulos et al., 1997; Krüger et al., 1998; Singleton et al., 2003; Chartier-Harlin et al., 2004; Zarranz et al., 2004; Appel-Cresswell et al., 2013, Lesage et al., 2013; Pasanen et al., 2014).