TF and neoplasm: The Thomsen-Friedenreich antigen (Galβ1-3GalNAc α-O-Ser/Thr) (TF, CD176) is a mucin-type O-linked disaccharide which is overexpressed in tumor cells and is associated with tumor progression, invasive growth, and high metastatic potential, which suggests its important function in cancer cell survival [10, 14, 42, 44].