The inhibition of the adhesion of circulating TF-positive tumor cells or micrometastasis to the endothelium via the galectin-3 pathway has been proposed as a mechanism for the antimetastatic action of TF-specific Abs [134], including JAA-F11 MAb, which is highly specific for alpha-anomeric TF [35, 39]. The gene discussed is LGALS3; the disease is neoplasm.