TF and neoplasm: In contrast to the adaptive AAbs to TAAs that appear during tumorigenesis, a decreased level of naturally occurring TF-specific Abs (TF Abs) in cancer patients has been known since the pioneered studies of the G. Springer group in the 1980s [15], but no further special in-depth analysis of this phenomenon has been done possibly because of the focus being shifted to the role of cell-mediated immunity (CMI) in tumor immunosurveillance.