TF and cancer: Several mechanisms have been proposed to explain the increased TF occurrence in cancer, such as alteration of the relative activities of glycosyltransferases that are responsible for the biosynthesis of complex O-glycans, the enhanced availability of the nucleotide sugar substrate UDP-galactose for the core 1 β1,3 Gal-transferase (the only enzyme which forms core 1 from the Tn antigen precursor), the acidification status of Golgi apparatus in cancer, and changes in the cellular Cosms (Core 1 beta1,3-Gal-T-specific molecular chaperone) expression [42].