Lio et al. [56] detected the levels of WFA+-CSF1R and total-CSF1R in 214 patients with liver diseases caused by HCV infection and found that patients with LC (n = 115) had significantly higher plasma levels of WFA+-CSF1R and total-CSF1R than the patients (n = 99) with chronic hepatitis (208.9 ng/ml vs. 82.3 ng/ml; 845.3 ng/ml vs. 536.4 ng/ml, respectively) and that the mortality was significantly higher in patients with WFA+-CSF1R levels ≥310 ng/ml (HR: 1.8), with an AUROC of 0.691. The gene discussed is CSF1R; the disease is chronic hepatitis.