Waidmann et al. [45] prospectively investigated 211 LC patients and found that these three CK-18-based cell death markers also could be potential biomarkers of severity of LC induced by other etiologies (mainly alcohol abuse and HCV infection), but only M65EpiDeath was associated with the patients prognosis, and interestingly, M65EpiDeath level was a factor for mortality in patients with compensated LC (HR: 11.483), but not decompensated LC. Here, KRT18 is linked to laryngotracheoesophageal cleft.