CALML3 and liver cancer: Further analyses of important genes in these pathways revealed that FOS (Fos proto-oncogene, AP-1 transcription factor subunit, degree = 54), LAMC2 (laminin subunit gamma 2, degree = 13), and CALML3 (calmodulin like 3, degree = 7) were the most significant gene nodes with high degrees indicating the pivotal role of these genes involved in liver cancer (Table 2).