Compared with the dexamethasone group, the concentrations of BALP and Ca significantly increased but the concentrations of TRACP and P decreased in the combination therapy group (P < 0.05), which is in accord with our hypothesis that the combination therapy of Wuweizi and dexamethasone in IPF rats can alleviate dexamethasone-induced GIOP. This evidence concerns the gene ACP5 and idiopathic pulmonary fibrosis.