Whole-exome sequencing analysis of 58,335 participants from the DiscovEHR study and 130,483 participants from four human genetic cohorts (including Duke Catheterization Genetics cohort, Copenhagen General Population Studies, the University of Pennsylvania Medicine BioBank, and the Taiwan Metabochip consortium) revealed that heterozygous ANGPTL3 LOF carriers with approximately 50% lower serum ANGPTL3 levels than noncarriers had a 39% lower probability of CAD [17]. This evidence concerns the gene ANGPTL3 and coronary artery disorder.