AGER and Anxiety: They showed that, in addition to the amelioration of anxiety and depressive like-behaviors, melatonin reversed DM-mediated reduction of S100B and GSH, and enhancement of AGE and MDA levels, indicating anxiolytic and antidepressant potentials in diabetic rats via normalizing oxidative stress, S100B, and AGE/AGER in the hippocampus and prefrontal cortex [69].