Furthermore, Zheng S and colleagues discovered that down-regulation of MIR31HG inhibited NSCLC cell proliferation, invasion and EMT phenotype via up-regulating E-cadherin expression, inhibiting Wnt/β-catenin cascade, and down-regulating expression of Twist1 and vimentin [2]. The gene discussed is TWIST1; the disease is non-small cell lung carcinoma.