In addition, researchers demonstrated possible significant inhibition of malignant CSC features or BMI1 knock-down by upregulating the miR-200c could so that ZEB1 or ZEB2 knockdown may enhance the miR-200c and suppress the BMI1 expressions in the ALDH1+/CD44+ HNSCC cells, which revealed that interactions between ZEB1/ZEB2, BMI1, and miR-200c detected the fate of the cancer stemness in OSCC. This evidence concerns the gene CD44 and head and neck squamous cell carcinoma.