JMJD6 and cancer: Currently, the increasing trend of documents showed the essential contribution of histone demethylases such as JARID1, KDM4, LSD1, KDM6B, KDM6A, KMD3, KDM5, and Jumonji domain–consisting of protein 6 (JMJD6) to the cancer stem cell phenotype in several kinds of cancers [61, 123–130].